Factors affecting statistical power in the detection of genetic association

Derek Gordon; Stephen J. Finch

doi:10.1172/JCI24756

Factors affecting statistical power in the detection of genetic association

Derek Gordon, Stephen J. Finch

Research output: Contribution to journal › Review article › peer-review

107 Scopus citations

Abstract

The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.

Original language	English (US)
Pages (from-to)	1408-1418
Number of pages	11
Journal	Journal of Clinical Investigation
Volume	115
Issue number	6
DOIs	https://doi.org/10.1172/JCI24756
State	Published - Jun 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine(all)

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10.1172/JCI24756

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title = "Factors affecting statistical power in the detection of genetic association",

abstract = "The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.",

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AB - The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.

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Factors affecting statistical power in the detection of genetic association

Abstract

All Science Journal Classification (ASJC) codes

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