Factors affecting statistical power in the detection of genetic association

Derek Gordon, Stephen J. Finch

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations

Abstract

The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.

Original languageEnglish (US)
Pages (from-to)1408-1418
Number of pages11
JournalJournal of Clinical Investigation
Volume115
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine

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