The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.
|Original language||English (US)|
|Number of pages||11|
|Journal||Journal of Clinical Investigation|
|State||Published - Jun 2005|
All Science Journal Classification (ASJC) codes