Failure of demonstrated clinical efficacy of antibiotic-bonded continuous ambulatory peritoneal dialysis (CAPD) catheters

S. Z. Trooskin, R. A. Harvey, T. W.J. Lennard, R. S. Greco

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Previous in vitro, in vivo, and a preliminary clinical report have demonstrated efficacy of noncovalently bonding antibiotics to the surface of continuous ambulatory peritoneal dialysis (CAPD) catheters in decreasing infectious complications. A large prospective randomized clinical trial was completed. Eighty-six patients with chronic renal failure were enrolled in the study and randomized to receive either a surfactant treated or untreated control catheter. All catheters were soaked in cefoxitin at the time of insertion. Groups were comparable in terms of pre-existing illnesses, age, and gender. No differences were shown in the incidence of catheter-tract infections, peritonitis or mechanical complications. There was also no differences in microbiologic culture results. Therefore, it is concluded that this clinical trial did not demonstrate a reduction in catheter-related infectious complications by antibiotic bonding.

Original languageEnglish (US)
Pages (from-to)57-59
Number of pages3
JournalPeritoneal Dialysis International
Volume10
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Nephrology

Keywords

  • Antibiotic bondings
  • Catheters
  • Exit-site infection
  • Peritonitis

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