Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population

Alda M. Ambrósio; James L. Kennedy; Fabio Macciardi; António Macedo; José Valente; Ana Dourado; Catarina R. Oliveira; Carlos Pato

doi:10.1016/j.psychres.2003.12.016

Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population

Alda M. Ambrósio, James L. Kennedy, Fabio Macciardi, António Macedo, José Valente, Ana Dourado, Catarina R. Oliveira, Carlos Pato

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Schizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample.

Original language	English (US)
Pages (from-to)	185-191
Number of pages	7
Journal	Psychiatry Research
Volume	125
Issue number	3
DOIs	https://doi.org/10.1016/j.psychres.2003.12.016
State	Published - Mar 15 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

Keywords

Association study
Candidate genes
Haplotypes
Linkage disequilibrium
Schizophrenia

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10.1016/j.psychres.2003.12.016

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title = "Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population",

abstract = "Schizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample.",

keywords = "Association study, Candidate genes, Haplotypes, Linkage disequilibrium, Schizophrenia",

author = "Ambr{\'o}sio, {Alda M.} and Kennedy, {James L.} and Fabio Macciardi and Ant{\'o}nio Macedo and Jos{\'e} Valente and Ana Dourado and Oliveira, {Catarina R.} and Carlos Pato",

note = "Funding Information: This work was supported by the Medical Research Council of Canada, the National Institute of Mental Health (USA) and Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, Portugal.",

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doi = "10.1016/j.psychres.2003.12.016",

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pages = "185--191",

journal = "Psychiatry Research",

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T1 - Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population

AU - Ambrósio, Alda M.

AU - Kennedy, James L.

AU - Macciardi, Fabio

AU - Macedo, António

AU - Valente, José

AU - Dourado, Ana

AU - Oliveira, Catarina R.

AU - Pato, Carlos

N1 - Funding Information: This work was supported by the Medical Research Council of Canada, the National Institute of Mental Health (USA) and Fundação para a Ciência e a Tecnologia, Portugal.

PY - 2004/3/15

Y1 - 2004/3/15

N2 - Schizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample.

AB - Schizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample.

KW - Association study

KW - Candidate genes

KW - Haplotypes

KW - Linkage disequilibrium

KW - Schizophrenia

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Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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