Feasibility and safety of peripheral blood stem cell collection in children with poor-prognosis solid tumors: A single center experience

I. Dolgopolov, M. Yankelevich, L. Andreeva, D. Mscheidze, D. Ijoguine, S. Siegel, G. Mentkevich

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This study reports the data of 32 children with poor-prognosis solid tumors who had 78 PBSC harvests on Fenwall CS-3000plus after mobilization mainly by different treatment protocol chemotherapy regimens followed by G- or GM-CSF (92% of patients) or by G-/GM-CSF alone (8%). Timing of procedure was predicted by studying the blood count. When the white blood cell and platelet count reached a median of 8.1 (0.9-37.3) and 95 (16-338) x 109/L, respectively, the median number of 2.7 (0. 005-16.8) x 106 CD34+/kg with 1.5 (0.005-11.6) x 106 CD34+/kg for 1 blood volume processed was obtained per procedure. In the group of 13 patients with low body weight (median 14 [10-20] kg) 32 leukophereses were performed. The extracorporal line was primed with donor red blood cells in the patients with the weight below 15 kg. No difference was observed in CD34+ content in harvests whether GM-CSF was begun on day +1 or on day +3 after chemotherapy.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalPediatric Hematology and Oncology
Volume16
Issue number4
DOIs
StatePublished - Jul 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Keywords

  • Children
  • GM/G-CSF
  • Harvest
  • Mobilizing regimens
  • PBSC

Fingerprint Dive into the research topics of 'Feasibility and safety of peripheral blood stem cell collection in children with poor-prognosis solid tumors: A single center experience'. Together they form a unique fingerprint.

Cite this