Female androgen insufficiency: The princeton consensus statement on definition, classification, and assessment

Gloria Bachmann, John Bancroft, Glenn Braunstein, Henry Burger, Susan Davis, Lorraine Dennerstein, Irwin Goldstein, Andre Guay, Sandra Leiblum, Rogerio Lobo, Morris Notelovitz, Raymond Rosen, Philip Sarrel, Barbara Sherwin, James Simon, Evan Simpson, Jan Shifren, Richard Spark, Abdul Traish

Research output: Contribution to journalArticlepeer-review

334 Scopus citations

Abstract

Objective: To evaluate the evidence for and against androgen insufficiency as a cause of sexual and other health-related problems in women and to make recommendations regarding definition, diagnosis, and assessment of androgen deficiency states in women. Design: Evaluation of peer-review literature and consensus conference of international experts. Setting: Multinational conference in the United States. Patient(s): Premenopausal and postmenopausal women with androgen deficiency. Intervention(s): Evaluation of peer-review literature and development of consensus panel guidelines. Result(s): The term "female androgen insufficiency" was defined as consisting of a pattern of clinical symptoms in the presence of decreased bioavailable T and normal estrogen status. Currently available assays were found to be lacking in sensitivity and reliability at the lower ranges, and the need for an equilibrium dialysis measure was strongly emphasized. Causes of androgen insufficiency in women were classified as ovarian, adrenal, hypothalamic-pituitary, drug-related, and idiopathic. A simplified management algorithm and clinical guidelines were proposed to assist clinicians in diagnosis and assessment. Androgen replacement is currently available in several forms, although none has been approved for treatment of sexual dysfunction or other common symptoms of female androgen insufficiency. Potential risks associated with treatment were identified, and the need for informed consent and careful monitoring was noted. Finally, the panel identified key goals and priorities for future research. Conclusion(s): A new definition of androgen insufficiency in women has been proposed along with consensus-based guidelines for clinical assessment and diagnosis. A simplified management algorithm for women with low androgen in the presence of clinical symptoms and normal estrogen status has also been proposed.

Original languageEnglish (US)
Pages (from-to)660-665
Number of pages6
JournalFertility and Sterility
Volume77
Issue number4
DOIs
StatePublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology

Keywords

  • Androgen deficiency states
  • Androgen replacement therapy
  • Bioavailable testosterone
  • Female sexual dysfunction
  • Low libido
  • Sex hormone-binding globulin

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