Fenfluramine-induced behavior changes in rats prefed serotonin-altering amounts of tryptophan and pyridoxine

Nam Soo Lee, George C. Wagner, J. Richard Trout, Hans Fisher

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3 Scopus citations


It has been well established that elevated dietary tryptophan (TRP) levels can increase brain serotonin concentrations, thereby influencing serotonergic transmission. We previously examined interaction between dietary substrate (TRP: 0.15 and 0.6%) and the cofactor precursor (pyridoxine HCl: 3 and 3,000 mg/kg) on brain serotonin metabolism, observing significant increases in serotonin concentrations from such dietary interaction. The present experiments were designed to explore possible behavioral consequences of the substrate-cofactor interaction. After the IP injection of fenfluramine (FA: at 5, 10, 15, and 20 mg/kg), serotonin-mediated behavior traits and the appearance of flushing were observed in rats fed experimental diets as stated above. With a 5 mg/kg dose of FA, a differential dietary effect was most visible. However, at higher FA levels (15 and 20 mg/kg), such dietary effects were no longer discernible. The appearance of flushing was also dependent on dietary TRP intake and the dosage of FA. These results indicate a clear substrate-cofactor interaction on certain serotonin-mediated behavior traits in the rat.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Issue number3
StatePublished - Mar 1988

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


  • Behavior
  • Brain
  • Fenfluramine
  • Hypothalamus
  • Serotonin
  • Tryptophan
  • Vitamin B

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