Fenfluramine-induced behavior changes in rats prefed serotonin-altering amounts of tryptophan and pyridoxine

Nam Soo Lee, George C. Wagner, J. Richard Trout, Hans Fisher

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

It has been well established that elevated dietary tryptophan (TRP) levels can increase brain serotonin concentrations, thereby influencing serotonergic transmission. We previously examined interaction between dietary substrate (TRP: 0.15 and 0.6%) and the cofactor precursor (pyridoxine HCl: 3 and 3,000 mg/kg) on brain serotonin metabolism, observing significant increases in serotonin concentrations from such dietary interaction. The present experiments were designed to explore possible behavioral consequences of the substrate-cofactor interaction. After the IP injection of fenfluramine (FA: at 5, 10, 15, and 20 mg/kg), serotonin-mediated behavior traits and the appearance of flushing were observed in rats fed experimental diets as stated above. With a 5 mg/kg dose of FA, a differential dietary effect was most visible. However, at higher FA levels (15 and 20 mg/kg), such dietary effects were no longer discernible. The appearance of flushing was also dependent on dietary TRP intake and the dosage of FA. These results indicate a clear substrate-cofactor interaction on certain serotonin-mediated behavior traits in the rat.

Original languageEnglish (US)
Pages (from-to)565-571
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume29
Issue number3
DOIs
StatePublished - Mar 1988

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Keywords

  • Behavior
  • Brain
  • Fenfluramine
  • Hypothalamus
  • Serotonin
  • Tryptophan
  • Vitamin B

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