Fibrillary astrocytes proliferate in response to brain injury. A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine

Norman Latov; Gajanan Nilaver; Earl A. Zimmerman; William G. Johnson; Ann Judith Silverman; Richard Defendini; Lucien Cote

doi:10.1016/0012-1606(79)90127-1

Fibrillary astrocytes proliferate in response to brain injury. A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine

Norman Latov, Gajanan Nilaver, Earl A. Zimmerman, William G. Johnson, Ann Judith Silverman, Richard Defendini, Lucien Cote

Research output: Contribution to journal › Article › peer-review

349 Scopus citations

Abstract

To determine whether fibrillary astrocytes proliferate in response to brain injury, cells identified as fibrillary astrocytes using immunoperoxidase technique for glial fibrillary acidic protein (GFAP) were examined for uptake of radiolabeled thymidine by autoradiography. In injured mouse brain, autoradiographic label was present over nuclei of immunoreactive fibrillary astrocytes in the lesion site 1 hr following injection of radiolabeled thymidine. The data suggest that fibrillary astrocytes which are sufficiently differentiated to accumulate GFAP retain the capacity to proliferate in response to injury.

Original language	English (US)
Pages (from-to)	381-384
Number of pages	4
Journal	Developmental Biology
Volume	72
Issue number	2
DOIs	https://doi.org/10.1016/0012-1606(79)90127-1
State	Published - Oct 1979
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Developmental Biology
Cell Biology

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10.1016/0012-1606(79)90127-1

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Latov, N., Nilaver, G., Zimmerman, E. A., Johnson, W. G., Silverman, A. J., Defendini, R., & Cote, L. (1979). Fibrillary astrocytes proliferate in response to brain injury. A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine. Developmental Biology, 72(2), 381-384. https://doi.org/10.1016/0012-1606(79)90127-1

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title = "Fibrillary astrocytes proliferate in response to brain injury. A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine",

abstract = "To determine whether fibrillary astrocytes proliferate in response to brain injury, cells identified as fibrillary astrocytes using immunoperoxidase technique for glial fibrillary acidic protein (GFAP) were examined for uptake of radiolabeled thymidine by autoradiography. In injured mouse brain, autoradiographic label was present over nuclei of immunoreactive fibrillary astrocytes in the lesion site 1 hr following injection of radiolabeled thymidine. The data suggest that fibrillary astrocytes which are sufficiently differentiated to accumulate GFAP retain the capacity to proliferate in response to injury.",

author = "Norman Latov and Gajanan Nilaver and Zimmerman, {Earl A.} and Johnson, {William G.} and Silverman, {Ann Judith} and Richard Defendini and Lucien Cote",

note = "Funding Information: I Supported by P.H.S. Grants HD10665 AM20337 (RAZ, AJS) and a Parkinson grant to Columbia University.",

year = "1979",

month = oct,

doi = "10.1016/0012-1606(79)90127-1",

language = "English (US)",

volume = "72",

pages = "381--384",

journal = "Developmental Biology",

issn = "0012-1606",

publisher = "Academic Press Inc.",

number = "2",

}

Latov, N, Nilaver, G, Zimmerman, EA, Johnson, WG, Silverman, AJ, Defendini, R & Cote, L 1979, 'Fibrillary astrocytes proliferate in response to brain injury. A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine', Developmental Biology, vol. 72, no. 2, pp. 381-384. https://doi.org/10.1016/0012-1606(79)90127-1

Fibrillary astrocytes proliferate in response to brain injury. A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine. / Latov, Norman; Nilaver, Gajanan; Zimmerman, Earl A. et al.
In: Developmental Biology, Vol. 72, No. 2, 10.1979, p. 381-384.

Research output: Contribution to journal › Article › peer-review

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T1 - Fibrillary astrocytes proliferate in response to brain injury. A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine

AU - Latov, Norman

AU - Nilaver, Gajanan

AU - Zimmerman, Earl A.

AU - Johnson, William G.

AU - Silverman, Ann Judith

AU - Defendini, Richard

AU - Cote, Lucien

N1 - Funding Information: I Supported by P.H.S. Grants HD10665 AM20337 (RAZ, AJS) and a Parkinson grant to Columbia University.

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N2 - To determine whether fibrillary astrocytes proliferate in response to brain injury, cells identified as fibrillary astrocytes using immunoperoxidase technique for glial fibrillary acidic protein (GFAP) were examined for uptake of radiolabeled thymidine by autoradiography. In injured mouse brain, autoradiographic label was present over nuclei of immunoreactive fibrillary astrocytes in the lesion site 1 hr following injection of radiolabeled thymidine. The data suggest that fibrillary astrocytes which are sufficiently differentiated to accumulate GFAP retain the capacity to proliferate in response to injury.

AB - To determine whether fibrillary astrocytes proliferate in response to brain injury, cells identified as fibrillary astrocytes using immunoperoxidase technique for glial fibrillary acidic protein (GFAP) were examined for uptake of radiolabeled thymidine by autoradiography. In injured mouse brain, autoradiographic label was present over nuclei of immunoreactive fibrillary astrocytes in the lesion site 1 hr following injection of radiolabeled thymidine. The data suggest that fibrillary astrocytes which are sufficiently differentiated to accumulate GFAP retain the capacity to proliferate in response to injury.

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Fibrillary astrocytes proliferate in response to brain injury. A study combining immunoperoxidase technique for glial fibrillary acidic protein and radioautography of tritiated thymidine

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