Filling the gaps in Richter syndrome: Options in the pipeline

Richter syndrome (RS) refers to the transformation of chronic lymphocytic leukemia or small lymphocytic lymphoma into an aggressive lymphoma. RS, in general, is associated with a poor prognosis despite aggressive medical therapy and therefore represents an unmet need. There is no established standard of care and novel therapies are needed. This article will summarize current understanding of the pathophysiology of the disease and current treatment options, including the role of novel targeted agents and stem cell transplantation.