First Responders: Innate Immunity to Helminths

Juan M. Inclan-Rico; Mark C. Siracusa

doi:10.1016/j.pt.2018.08.007

First Responders: Innate Immunity to Helminths

Juan M. Inclan-Rico, Mark C. Siracusa

New Jersey Medical School (NJMS), Center for Immunity and Inflammation (CII)

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

Helminth infections represent a significant public health concern resulting in devastating morbidity and economic consequences across the globe. Helminths migrate through mucosal sites causing tissue damage and the induction of type 2 immune responses. Antihelminth protection relies on the mobilization and activation of multiple immune cells, including type 2 innate lymphocytes (ILC2s), basophils, mast cells, macrophages, and hematopoietic stem/progenitor cells. Further, epithelial cells and neurons have been recognized as important regulators of type 2 immunity. Collectively, these pathways stimulate host-protective responses necessary for worm expulsion and the healing of affected tissues. In this review we focus on the innate immune pathways that regulate immunity to helminth parasites and describe how better understanding of these pathways may lead to the development of new therapeutic strategies.

Original language	English (US)
Pages (from-to)	861-880
Number of pages	20
Journal	Trends in Parasitology
Volume	34
Issue number	10
DOIs	https://doi.org/10.1016/j.pt.2018.08.007
State	Published - Oct 2018

All Science Journal Classification (ASJC) codes

Parasitology
Infectious Diseases

Keywords

Mucosal Immunology
helminth parasites
innate immunity
type 2 cytokines

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10.1016/j.pt.2018.08.007

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title = "First Responders: Innate Immunity to Helminths",

abstract = "Helminth infections represent a significant public health concern resulting in devastating morbidity and economic consequences across the globe. Helminths migrate through mucosal sites causing tissue damage and the induction of type 2 immune responses. Antihelminth protection relies on the mobilization and activation of multiple immune cells, including type 2 innate lymphocytes (ILC2s), basophils, mast cells, macrophages, and hematopoietic stem/progenitor cells. Further, epithelial cells and neurons have been recognized as important regulators of type 2 immunity. Collectively, these pathways stimulate host-protective responses necessary for worm expulsion and the healing of affected tissues. In this review we focus on the innate immune pathways that regulate immunity to helminth parasites and describe how better understanding of these pathways may lead to the development of new therapeutic strategies.",

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note = "Funding Information: We thank members of the Center for Immunity and Inflammation and the Siracusa laboratory for discussions and critical reading. We would like to thank Servier Medical Art (http://www.servier.com) for figure graphics. This work was supported by the National Institutes of Health (1R01AI123224 and 1R01AI131634-01A1 to MCS) and the New Jersey Heath Foundation. Funding Information: We thank members of the Center for Immunity and Inflammation and the Siracusa laboratory for discussions and critical reading. We would like to thank Servier Medical Art ( http://www.servier.com ) for figure graphics. This work was supported by the National Institutes of Health ( 1R01AI123224 and 1R01AI131634-01A1 to MCS) and the New Jersey Heath Foundation . Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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N2 - Helminth infections represent a significant public health concern resulting in devastating morbidity and economic consequences across the globe. Helminths migrate through mucosal sites causing tissue damage and the induction of type 2 immune responses. Antihelminth protection relies on the mobilization and activation of multiple immune cells, including type 2 innate lymphocytes (ILC2s), basophils, mast cells, macrophages, and hematopoietic stem/progenitor cells. Further, epithelial cells and neurons have been recognized as important regulators of type 2 immunity. Collectively, these pathways stimulate host-protective responses necessary for worm expulsion and the healing of affected tissues. In this review we focus on the innate immune pathways that regulate immunity to helminth parasites and describe how better understanding of these pathways may lead to the development of new therapeutic strategies.

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First Responders: Innate Immunity to Helminths

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