Flow-induced prostacyclin production is mediated by a pertussis toxin-sensitive G protein

Francois Berthiaume, John A. Frangos

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Fluid flow and several other agonists induce prostacyclin (PGI2) production in endothelial cells, G proteins mediate the response of a large number of hormones such as histamine, but the transduction pathway of the flow signal is unclear. We found that GDPβS and pertussis toxin inhibited flow-induced prostacyclin production in human umbilical vein endothelial cells. In addition, flow potentiated the histamine-induced production of PGI2. This suggests that flow stimulates prostacyclin production via a pertussis toxin-sensitive G protein and modulates the stimulus-response coupling of other agonists.

Original languageEnglish (US)
Pages (from-to)277-279
Number of pages3
JournalFEBS Letters
Volume308
Issue number3
DOIs
StatePublished - Aug 24 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Keywords

  • Endothelial cell
  • G protein
  • Histamine
  • Pertussis toxin
  • Prostacyclin
  • Shear stress

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