Fluid flow analysis in microfluidic devices by spectral-domain optical Doppler tomography

Mark C. Pierce, Chulmin Joo, Barry Cense, Eli Weinberg, B. Hyle Park, Mircea Mujat, Jeffrey Borenstein, Guillermo J. Tearney, Brett E. Bouma, Johannes F. De Boer

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


Microfluidic devices are becoming increasingly popular for many applications, enabling biological and chemical reactions to be performed with nano- and picoliter sample volumes. Accurate measurement and monitoring of fluid flow behavior in the small channels of microfluidic systems is important for evaluating the performance of existing devices, and in the modeling and design of new microfluidic networks. We present here the results of experiments using spectral-domain optical Doppler tomography (SD-ODT) to measure fluid flow in single-layer microfluidic devices. The principles behind flow imaging with SD-ODT are reviewed, a method for velocity calibration is described, and cross-sectional and en-face images of fluid velocity in microfluidic channels are presented.

Original languageEnglish (US)
Article number47
Pages (from-to)271-275
Number of pages5
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2005
Externally publishedYes
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States
Duration: Jan 23 2005Jan 26 2005

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


  • Fluid dynamics
  • Fourier-domain
  • Microfluidic devices
  • Non-invasive imaging
  • Optical coherence tomography


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