fMRI study of acupuncture-induced periaqueductal gray activity in humans

Wen Ching Liu; Susan C. Feldman; Dane B. Cook; Dung Liang Hung; Teresa Xu; Andrew J. Kalnin; Barry R. Komisaruk

doi:10.1097/00001756-200408260-00021

fMRI study of acupuncture-induced periaqueductal gray activity in humans

Wen Ching Liu, Susan C. Feldman, Dane B. Cook, Dung Liang Hung, Teresa Xu, Andrew J. Kalnin, Barry R. Komisaruk

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

BOLD fMRI was used to study acupuncture-induced activation (increase in the BOLD signal from undetectable) of the periaqueductal gray (PAG) and two somatosensory cortical areas in seven healthy human subjects. Mechanical stimulation (push-pull) was given to the LI4 (Hoku) acupoint or to a non-acupoint. The stimulation paradigm consisted of 5 runs, each consisting of four 30 s On/ 30 s OFF periods over 30 min. The scan for each ON period was analyzed individually. The PAG and cortical areas showed different activity patterns. PAG activity was episodic and reliably demonstrated after 20-25 min of stimulation; both cortical areas, however, were active >90% of the time. Stimulation of a non-acupoint (leg) resulted in reduced levels of PAG and cortical activity.

Original language	English (US)
Pages (from-to)	1937-1940
Number of pages	4
Journal	NeuroReport
Volume	15
Issue number	12
DOIs	https://doi.org/10.1097/00001756-200408260-00021
State	Published - Aug 26 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

Keywords

Acupuncture
Periaqueductal gray (PAG)
Somatosensory cortex
fMRI

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10.1097/00001756-200408260-00021

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title = "fMRI study of acupuncture-induced periaqueductal gray activity in humans",

abstract = "BOLD fMRI was used to study acupuncture-induced activation (increase in the BOLD signal from undetectable) of the periaqueductal gray (PAG) and two somatosensory cortical areas in seven healthy human subjects. Mechanical stimulation (push-pull) was given to the LI4 (Hoku) acupoint or to a non-acupoint. The stimulation paradigm consisted of 5 runs, each consisting of four 30 s On/ 30 s OFF periods over 30 min. The scan for each ON period was analyzed individually. The PAG and cortical areas showed different activity patterns. PAG activity was episodic and reliably demonstrated after 20-25 min of stimulation; both cortical areas, however, were active >90% of the time. Stimulation of a non-acupoint (leg) resulted in reduced levels of PAG and cortical activity.",

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author = "Liu, {Wen Ching} and Feldman, {Susan C.} and Cook, {Dane B.} and Hung, {Dung Liang} and Teresa Xu and Kalnin, {Andrew J.} and Komisaruk, {Barry R.}",

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AU - Liu, Wen Ching

AU - Feldman, Susan C.

AU - Cook, Dane B.

AU - Hung, Dung Liang

AU - Xu, Teresa

AU - Kalnin, Andrew J.

AU - Komisaruk, Barry R.

PY - 2004/8/26

Y1 - 2004/8/26

N2 - BOLD fMRI was used to study acupuncture-induced activation (increase in the BOLD signal from undetectable) of the periaqueductal gray (PAG) and two somatosensory cortical areas in seven healthy human subjects. Mechanical stimulation (push-pull) was given to the LI4 (Hoku) acupoint or to a non-acupoint. The stimulation paradigm consisted of 5 runs, each consisting of four 30 s On/ 30 s OFF periods over 30 min. The scan for each ON period was analyzed individually. The PAG and cortical areas showed different activity patterns. PAG activity was episodic and reliably demonstrated after 20-25 min of stimulation; both cortical areas, however, were active >90% of the time. Stimulation of a non-acupoint (leg) resulted in reduced levels of PAG and cortical activity.

AB - BOLD fMRI was used to study acupuncture-induced activation (increase in the BOLD signal from undetectable) of the periaqueductal gray (PAG) and two somatosensory cortical areas in seven healthy human subjects. Mechanical stimulation (push-pull) was given to the LI4 (Hoku) acupoint or to a non-acupoint. The stimulation paradigm consisted of 5 runs, each consisting of four 30 s On/ 30 s OFF periods over 30 min. The scan for each ON period was analyzed individually. The PAG and cortical areas showed different activity patterns. PAG activity was episodic and reliably demonstrated after 20-25 min of stimulation; both cortical areas, however, were active >90% of the time. Stimulation of a non-acupoint (leg) resulted in reduced levels of PAG and cortical activity.

KW - Acupuncture

KW - Periaqueductal gray (PAG)

KW - Somatosensory cortex

KW - fMRI

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JO - NeuroReport

JF - NeuroReport

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ER -

fMRI study of acupuncture-induced periaqueductal gray activity in humans

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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