TY - JOUR
T1 - Forced oscillation technique in veterans with preserved spirometry and chronic respiratory symptoms
AU - Butzko, Ryan P.
AU - Sotolongo, Anays M.
AU - Helmer, Drew A.
AU - Klein-Adams, Jacquelyn C.
AU - Osinubi, Omowunmi Y.
AU - Berman, Andrew R.
AU - Ortiz-Pacheco, Ronaldo
AU - Falvo, Michael J.
N1 - Publisher Copyright:
© 2018
PY - 2019/2
Y1 - 2019/2
N2 - Purpose: To evaluate the utility of the forced oscillation technique (FOT) among military veterans with preserved spirometry and chronic unexplained respiratory symptoms. Methods: 178 veterans referred for evaluation of unexplained respiratory symptoms completed pulmonary function testing and FOT. Preserved spirometry was defined as FEV 1 /FVC, FEV 1 and FVC ≥ 5th percentile. Frequency dependence of resistance (R4-R20) and reactance area (AX) were assessed via FOT, and R4-R20 ≥ 20% and AX ≥ 95th percentile were considered abnormal. Results: Spirometry was preserved in 71.3%, of whom 124 had acceptable FOT data. 93 of 124 (75.0%) veterans with preserved spirometry had one or more abnormal findings on FOT. Veterans with abnormal R4-R20 and/or AX had reduced FVC, FEV 1 , FEF 25-75 , and diffusing capacity (% predicted) in comparison to those with Normal FOT (p = 0.030 to p < 0.001). Conclusions: In our referral sample, distal airway dysfunction in the presence of preserved spirometry appears common and may represent an at-risk group requiring closer surveillance.
AB - Purpose: To evaluate the utility of the forced oscillation technique (FOT) among military veterans with preserved spirometry and chronic unexplained respiratory symptoms. Methods: 178 veterans referred for evaluation of unexplained respiratory symptoms completed pulmonary function testing and FOT. Preserved spirometry was defined as FEV 1 /FVC, FEV 1 and FVC ≥ 5th percentile. Frequency dependence of resistance (R4-R20) and reactance area (AX) were assessed via FOT, and R4-R20 ≥ 20% and AX ≥ 95th percentile were considered abnormal. Results: Spirometry was preserved in 71.3%, of whom 124 had acceptable FOT data. 93 of 124 (75.0%) veterans with preserved spirometry had one or more abnormal findings on FOT. Veterans with abnormal R4-R20 and/or AX had reduced FVC, FEV 1 , FEF 25-75 , and diffusing capacity (% predicted) in comparison to those with Normal FOT (p = 0.030 to p < 0.001). Conclusions: In our referral sample, distal airway dysfunction in the presence of preserved spirometry appears common and may represent an at-risk group requiring closer surveillance.
KW - Environmental exposure
KW - Forced oscillation technique
KW - Respiratory
KW - Signs and symptoms
KW - Small airways
KW - Veterans health
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U2 - 10.1016/j.resp.2018.11.012
DO - 10.1016/j.resp.2018.11.012
M3 - Article
C2 - 30508589
AN - SCOPUS:85057615773
SN - 1569-9048
VL - 260
SP - 8
EP - 16
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
ER -