TY - JOUR
T1 - Forced oscillation technique in veterans with preserved spirometry and chronic respiratory symptoms
AU - Butzko, Ryan P.
AU - Sotolongo, Anays M.
AU - Helmer, Drew A.
AU - Klein-Adams, Jacquelyn C.
AU - Osinubi, Omowunmi Y.
AU - Berman, Andrew R.
AU - Ortiz-Pacheco, Ronaldo
AU - Falvo, Michael J.
N1 - Funding Information:
The authors gratefully acknowledge those who contributed to the evaluation and care of the veterans in our sample, especially Mr. Duncan Ndirangu and Ms. Nancy Eager. This work is supported in part by the Department of Veterans Affairs (VA) Clinical Science Research & Development Program ( I01CX001515 and I01CX001329 ; MJF), VA Post-Deployment Health Service and the New Jersey War Related Illness and Injury Study Center . The contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.
Publisher Copyright:
© 2018
PY - 2019/2
Y1 - 2019/2
N2 - Purpose: To evaluate the utility of the forced oscillation technique (FOT) among military veterans with preserved spirometry and chronic unexplained respiratory symptoms. Methods: 178 veterans referred for evaluation of unexplained respiratory symptoms completed pulmonary function testing and FOT. Preserved spirometry was defined as FEV 1 /FVC, FEV 1 and FVC ≥ 5th percentile. Frequency dependence of resistance (R4-R20) and reactance area (AX) were assessed via FOT, and R4-R20 ≥ 20% and AX ≥ 95th percentile were considered abnormal. Results: Spirometry was preserved in 71.3%, of whom 124 had acceptable FOT data. 93 of 124 (75.0%) veterans with preserved spirometry had one or more abnormal findings on FOT. Veterans with abnormal R4-R20 and/or AX had reduced FVC, FEV 1 , FEF 25-75 , and diffusing capacity (% predicted) in comparison to those with Normal FOT (p = 0.030 to p < 0.001). Conclusions: In our referral sample, distal airway dysfunction in the presence of preserved spirometry appears common and may represent an at-risk group requiring closer surveillance.
AB - Purpose: To evaluate the utility of the forced oscillation technique (FOT) among military veterans with preserved spirometry and chronic unexplained respiratory symptoms. Methods: 178 veterans referred for evaluation of unexplained respiratory symptoms completed pulmonary function testing and FOT. Preserved spirometry was defined as FEV 1 /FVC, FEV 1 and FVC ≥ 5th percentile. Frequency dependence of resistance (R4-R20) and reactance area (AX) were assessed via FOT, and R4-R20 ≥ 20% and AX ≥ 95th percentile were considered abnormal. Results: Spirometry was preserved in 71.3%, of whom 124 had acceptable FOT data. 93 of 124 (75.0%) veterans with preserved spirometry had one or more abnormal findings on FOT. Veterans with abnormal R4-R20 and/or AX had reduced FVC, FEV 1 , FEF 25-75 , and diffusing capacity (% predicted) in comparison to those with Normal FOT (p = 0.030 to p < 0.001). Conclusions: In our referral sample, distal airway dysfunction in the presence of preserved spirometry appears common and may represent an at-risk group requiring closer surveillance.
KW - Environmental exposure
KW - Forced oscillation technique
KW - Respiratory
KW - Signs and symptoms
KW - Small airways
KW - Veterans health
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U2 - 10.1016/j.resp.2018.11.012
DO - 10.1016/j.resp.2018.11.012
M3 - Article
C2 - 30508589
AN - SCOPUS:85057615773
VL - 260
SP - 8
EP - 16
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
ER -