Form and function: The laminin family of heterotrimers

Holly Colognato, Peter D. Yurchenco

Research output: Contribution to journalReview articlepeer-review

990 Scopus citations

Abstract

The laminins are a family of glycoproteins that provide an integral part of the structural scaffolding of basement membranes in almost every animal tissue. Each laminin is a heterotrimer assembled from α, β, and γ chain subunits, secreted and incorporated into cell-associated extracellular matrices. The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. Through these interactions, laminins critically contribute to cell differentiation, cell shape and movement, maintenance of tissue phenotypes, and promotion of tissue survival. Recent advances in the characterization of genetic disruptions in humans, mice, nematodes and flies have revealed developmental roles for the different laminin subunits in diverse cell types, affecting differentiation from blastocyst formation to the post-natal period. These genetic defects have challenged some of the previous concepts about basement membranes and have shed new light on the diversity and complexity of laminin functions as well as established the molecular basis of several human diseases. (C) 2000 Wiley- Liss, Inc.

Original languageEnglish (US)
Pages (from-to)213-234
Number of pages22
JournalDevelopmental Dynamics
Volume218
Issue number2
DOIs
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Keywords

  • Basement membrane
  • Cell surface receptors
  • Extracellular matrix
  • Kidney development
  • Neuromuscular function

Fingerprint Dive into the research topics of 'Form and function: The laminin family of heterotrimers'. Together they form a unique fingerprint.

Cite this