Formal [4 + 2] cycloaddition of imines with alkoxyisocoumarins

Claire L. Jarvis, Neyra M. Jemal, Spencer Knapp, Daniel Seidel

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A new preparation of δ-lactams is reported. In the presence of a Lewis acid promoter, alkoxyisocoumarins engage a range of N-aryl and N-alkyl imines to form δ-lactams with a pendent carboalkoxy substituent. A sulfonamide-thiourea catalyst enables the synthesis of these products in moderate to good enantioselectivities.

Original languageEnglish (US)
Pages (from-to)4231-4235
Number of pages5
JournalOrganic and Biomolecular Chemistry
Issue number23
StatePublished - 2018

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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