Formulated extract from multiple citrus peels impairs dendritic cell functions and attenuates allergic contact hypersensitivity

Shiming Li, Yi Chin Lin, Chi Tang Ho, Ping Yi Lin, Michiko Suzawa, Hsin Chieh Wang, Ching Liang Chu, Der Yuan Chen, Chi Chen Lin

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

It has been reported that gold lotion (GL), a formulated product made from the peels of six citrus fruits, has many pharmacological properties, such as anti-tumor, antioxidant, and anti-inflammatory activities. In this study, we investigated the immunomodulatory effect of GL on lipopolysaccharide (LPS) stimulated mouse bone marrow-derived DC maturation and function. Our experimental results have shown that GL significantly impaired the pro-inflammatory cytokine and chemokine secretion, suppressed the expression of major histocompatibility complex class I/II and costimulatory molecules (CD40, CD80 and CD86), increased phagocytic capacity, and reduced propensity to stimulate the autologous CD4+ and CD8+ T cell proliferation of LPS-induced DCs. Furthermore, we found that oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models. Subsequently, our molecular mechanism studies showed that GL interfered with LPS-induced MAPK-JNK, p38 phosphorylation and nuclear translocation of NF-κB p65. In an essence, these findings are the first report to provide new insight in the immunopharmacological role of GL in terms of its effects on DC.

Original languageEnglish (US)
Pages (from-to)12-23
Number of pages12
JournalInternational Immunopharmacology
Volume20
Issue number1
DOIs
StatePublished - May 2014

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Keywords

  • Citrus
  • Contact hypersensitivity (CHS)
  • Dendritic cells
  • Peels
  • T cells

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