Forssman Glycolipid Variants of Dog Gastric Mucosa: Structure of a Branched Ceramide Octasaccharide

Bronislaw L. SLOMIANY, Amalia SLOMIANY

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A fucose‐containing ceramide octasaccharide exhibiting Forssman antigenic activity, and reacting in human H anti‐H and anti‐A systems, was isolated from water‐soluble glycolipids of dog gastric mucosa. Defucosylation of the glycolipid resulted in the loss of H‐activity, but had no effect on its Forssman nor blood‐group A antigenic activity. The branched structure of glycolipid was identified by partial acid hydrolysis, sequential degradation with specific glycosidases and comparison of the permethylation products of the native and enzyme‐degraded compound. The structure of this glycolipid is proposed to be: (Formula Presented.)

Original languageEnglish (US)
Pages (from-to)105-111
Number of pages7
JournalEuropean Journal of Biochemistry
Volume83
Issue number1
DOIs
StatePublished - Feb 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry

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