Frozen naphthalocyanine micelles for intestinal imaging

Yumiao Zhang; Mansik Jeon; Laurie J. Rich; Hao Hong; Jumin Geng; Yin Zhang; Sixiang Shi; Todd E. Barnhart; Paschalis Alexandridis; Jan D. Huizinga; Mukund Seshadri; Weibo Cai; Chuhong Kim; Jonathan F. Lovell

doi:10.1109/NEBEC.2015.7117210

Frozen naphthalocyanine micelles for intestinal imaging

Yumiao Zhang, Mansik Jeon, Laurie J. Rich, Hao Hong, Jumin Geng, Yin Zhang, Sixiang Shi, Todd E. Barnhart, Paschalis Alexandridis, Jan D. Huizinga, Mukund Seshadri, Weibo Cai, Chuhong Kim, Jonathan F. Lovell

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Here we report the development of a family of nanoparticles that can withstand the harsh conditions of the stomach and intestine, avoid systemic absorption, and provide good optical contrast for photoacoustic imaging. The hydrophobicity of naphthalocyanine dyes was exploited to generate frozen micelles (nanonaps), with tunable near-infrared absorption. Nanonaps, following oral administration in mice, passed safely through the gastrointestinal tract. Non-invasive, non-ionizing photoacoustic techniques were used to visualize nanonap intestinal distribution with low background and remarkable resolution, and enabled real-time intestinal functional imaging with ultrasound co-registration.

Original language	English (US)
Title of host publication	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781479983605
DOIs	https://doi.org/10.1109/NEBEC.2015.7117210
State	Published - Jun 2 2015
Externally published	Yes
Event	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States Duration: Apr 17 2015 → Apr 19 2015

Publication series

Name	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

Other

Other	2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Country/Territory	United States
City	Troy
Period	4/17/15 → 4/19/15

All Science Journal Classification (ASJC) codes

Biotechnology
Cancer Research
Cell Biology
Molecular Medicine
Biomedical Engineering
Control and Systems Engineering

Access to Document

10.1109/NEBEC.2015.7117210

Cite this

Zhang, Y., Jeon, M., Rich, L. J., Hong, H., Geng, J., Zhang, Y., Shi, S., Barnhart, T. E., Alexandridis, P., Huizinga, J. D., Seshadri, M., Cai, W., Kim, C., & Lovell, J. F. (2015). Frozen naphthalocyanine micelles for intestinal imaging. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 Article 7117210 (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBEC.2015.7117210

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title = "Frozen naphthalocyanine micelles for intestinal imaging",

abstract = "Here we report the development of a family of nanoparticles that can withstand the harsh conditions of the stomach and intestine, avoid systemic absorption, and provide good optical contrast for photoacoustic imaging. The hydrophobicity of naphthalocyanine dyes was exploited to generate frozen micelles (nanonaps), with tunable near-infrared absorption. Nanonaps, following oral administration in mice, passed safely through the gastrointestinal tract. Non-invasive, non-ionizing photoacoustic techniques were used to visualize nanonap intestinal distribution with low background and remarkable resolution, and enabled real-time intestinal functional imaging with ultrasound co-registration.",

author = "Yumiao Zhang and Mansik Jeon and Rich, {Laurie J.} and Hao Hong and Jumin Geng and Yin Zhang and Sixiang Shi and Barnhart, {Todd E.} and Paschalis Alexandridis and Huizinga, {Jan D.} and Mukund Seshadri and Weibo Cai and Chuhong Kim and Lovell, {Jonathan F.}",

note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 ; Conference date: 17-04-2015 Through 19-04-2015",

year = "2015",

month = jun,

day = "2",

doi = "10.1109/NEBEC.2015.7117210",

language = "English (US)",

series = "2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

booktitle = "2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015",

address = "United States",

}

Zhang, Y, Jeon, M, Rich, LJ, Hong, H, Geng, J, Zhang, Y, Shi, S, Barnhart, TE, Alexandridis, P, Huizinga, JD, Seshadri, M, Cai, W, Kim, C & Lovell, JF 2015, Frozen naphthalocyanine micelles for intestinal imaging. in 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015., 7117210, 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Institute of Electrical and Electronics Engineers Inc., 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Troy, United States, 4/17/15. https://doi.org/10.1109/NEBEC.2015.7117210

Frozen naphthalocyanine micelles for intestinal imaging. / Zhang, Yumiao; Jeon, Mansik; Rich, Laurie J. et al.
2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7117210 (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Zhang, Yumiao

AU - Jeon, Mansik

AU - Rich, Laurie J.

AU - Hong, Hao

AU - Geng, Jumin

AU - Zhang, Yin

AU - Shi, Sixiang

AU - Barnhart, Todd E.

AU - Alexandridis, Paschalis

AU - Huizinga, Jan D.

AU - Seshadri, Mukund

AU - Cai, Weibo

AU - Kim, Chuhong

AU - Lovell, Jonathan F.

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N2 - Here we report the development of a family of nanoparticles that can withstand the harsh conditions of the stomach and intestine, avoid systemic absorption, and provide good optical contrast for photoacoustic imaging. The hydrophobicity of naphthalocyanine dyes was exploited to generate frozen micelles (nanonaps), with tunable near-infrared absorption. Nanonaps, following oral administration in mice, passed safely through the gastrointestinal tract. Non-invasive, non-ionizing photoacoustic techniques were used to visualize nanonap intestinal distribution with low background and remarkable resolution, and enabled real-time intestinal functional imaging with ultrasound co-registration.

AB - Here we report the development of a family of nanoparticles that can withstand the harsh conditions of the stomach and intestine, avoid systemic absorption, and provide good optical contrast for photoacoustic imaging. The hydrophobicity of naphthalocyanine dyes was exploited to generate frozen micelles (nanonaps), with tunable near-infrared absorption. Nanonaps, following oral administration in mice, passed safely through the gastrointestinal tract. Non-invasive, non-ionizing photoacoustic techniques were used to visualize nanonap intestinal distribution with low background and remarkable resolution, and enabled real-time intestinal functional imaging with ultrasound co-registration.

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T3 - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

BT - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

Y2 - 17 April 2015 through 19 April 2015

ER -

Frozen naphthalocyanine micelles for intestinal imaging

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