Function of hepatocyte co-cultures in a microfabricated flat-plate bioreactor with internal membrane oxygenator

Arno W. Tilles; Harihara Baskaran; Martin L. Yarmush; Mehmet Toner

Function of hepatocyte co-cultures in a microfabricated flat-plate bioreactor with internal membrane oxygenator

Arno W. Tilles, Harihara Baskaran, Martin L. Yarmush, Mehmet Toner

School of Engineering, Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

The development of an efficient bioartificial liver device requires maintaining hepatocytes in vivo-like conditions without substrate limitations. Hepatocytes, being highly metabolic, require adequate oxygenation to perform optimally. Describe is the efficacy of an internal membrane oxygenator (IMO) within a microchannel flat-plate bioreactor. The viability of rat hepatocytes cultured as a monolayer and the synthetic function of rat hepatocytes co-cultured with 3T3-J2 fibroblasts under perfusion conditions within the bioreactor are reported.

Original language	English (US)
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
State	Published - Dec 1 2000
Event	2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA Duration: Oct 12 2000 → Oct 14 2000

All Science Journal Classification (ASJC) codes

Biomedical Engineering

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title = "Function of hepatocyte co-cultures in a microfabricated flat-plate bioreactor with internal membrane oxygenator",

abstract = "The development of an efficient bioartificial liver device requires maintaining hepatocytes in vivo-like conditions without substrate limitations. Hepatocytes, being highly metabolic, require adequate oxygenation to perform optimally. Describe is the efficacy of an internal membrane oxygenator (IMO) within a microchannel flat-plate bioreactor. The viability of rat hepatocytes cultured as a monolayer and the synthetic function of rat hepatocytes co-cultured with 3T3-J2 fibroblasts under perfusion conditions within the bioreactor are reported.",

author = "Tilles, {Arno W.} and Harihara Baskaran and Yarmush, {Martin L.} and Mehmet Toner",

year = "2000",

month = dec,

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journal = "Annals of Biomedical Engineering",

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T1 - Function of hepatocyte co-cultures in a microfabricated flat-plate bioreactor with internal membrane oxygenator

AU - Tilles, Arno W.

AU - Baskaran, Harihara

AU - Yarmush, Martin L.

AU - Toner, Mehmet

PY - 2000/12/1

Y1 - 2000/12/1

N2 - The development of an efficient bioartificial liver device requires maintaining hepatocytes in vivo-like conditions without substrate limitations. Hepatocytes, being highly metabolic, require adequate oxygenation to perform optimally. Describe is the efficacy of an internal membrane oxygenator (IMO) within a microchannel flat-plate bioreactor. The viability of rat hepatocytes cultured as a monolayer and the synthetic function of rat hepatocytes co-cultured with 3T3-J2 fibroblasts under perfusion conditions within the bioreactor are reported.

AB - The development of an efficient bioartificial liver device requires maintaining hepatocytes in vivo-like conditions without substrate limitations. Hepatocytes, being highly metabolic, require adequate oxygenation to perform optimally. Describe is the efficacy of an internal membrane oxygenator (IMO) within a microchannel flat-plate bioreactor. The viability of rat hepatocytes cultured as a monolayer and the synthetic function of rat hepatocytes co-cultured with 3T3-J2 fibroblasts under perfusion conditions within the bioreactor are reported.

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M3 - Conference article

AN - SCOPUS:0034512946

VL - 28

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - SUPPL. 1

T2 - 2000 Annual Fall Meeting of the Biomedical Engineering Society

Y2 - 12 October 2000 through 14 October 2000

ER -