Function of hepatocyte co-cultures in a microfabricated flat-plate bioreactor with internal membrane oxygenator

Arno W. Tilles, Harihara Baskaran, Martin L. Yarmush, Mehmet Toner

Research output: Contribution to journalConference articlepeer-review

Abstract

The development of an efficient bioartificial liver device requires maintaining hepatocytes in vivo-like conditions without substrate limitations. Hepatocytes, being highly metabolic, require adequate oxygenation to perform optimally. Describe is the efficacy of an internal membrane oxygenator (IMO) within a microchannel flat-plate bioreactor. The viability of rat hepatocytes cultured as a monolayer and the synthetic function of rat hepatocytes co-cultured with 3T3-J2 fibroblasts under perfusion conditions within the bioreactor are reported.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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