TY - JOUR
T1 - Functional characterization of the drosophila Hmt4-20/Suv4-20 histone methyltransferase
AU - Sakaguchi, Ayako
AU - Karachentsev, Dmitry
AU - Seth-Pasricha, Mansha
AU - Druzhinina, Marina
AU - Steward, Ruth
PY - 2008/5
Y1 - 2008/5
N2 - Di- and trimethylation of histone H4 lysine20 (H4K20) are thought to play an important role in controlling gene expression in vertebrates and in Drosophila. By inducing a null mutation in Drosophila Suv4-20, we show that it encodes the histone H4 lysine20 di- and trimethyltransferase. In Suv4-20 mutants, the H4K20 di- and trimethyl marks are strongly reduced or absent, and the monomethyl mark is significantly increased. We find that even with this biochemical function, Suv4-20 is not required for survival and does not control position-effect variegation (PEV).
AB - Di- and trimethylation of histone H4 lysine20 (H4K20) are thought to play an important role in controlling gene expression in vertebrates and in Drosophila. By inducing a null mutation in Drosophila Suv4-20, we show that it encodes the histone H4 lysine20 di- and trimethyltransferase. In Suv4-20 mutants, the H4K20 di- and trimethyl marks are strongly reduced or absent, and the monomethyl mark is significantly increased. We find that even with this biochemical function, Suv4-20 is not required for survival and does not control position-effect variegation (PEV).
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U2 - 10.1534/genetics.108.087650
DO - 10.1534/genetics.108.087650
M3 - Article
C2 - 18493056
AN - SCOPUS:52049085575
SN - 0016-6731
VL - 179
SP - 317
EP - 322
JO - Genetics
JF - Genetics
IS - 1
ER -