Functional characterization of the drosophila Hmt4-20/Suv4-20 histone methyltransferase

Ayako Sakaguchi, Dmitry Karachentsev, Mansha Seth-Pasricha, Marina Druzhinina, Ruth Steward

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Di- and trimethylation of histone H4 lysine20 (H4K20) are thought to play an important role in controlling gene expression in vertebrates and in Drosophila. By inducing a null mutation in Drosophila Suv4-20, we show that it encodes the histone H4 lysine20 di- and trimethyltransferase. In Suv4-20 mutants, the H4K20 di- and trimethyl marks are strongly reduced or absent, and the monomethyl mark is significantly increased. We find that even with this biochemical function, Suv4-20 is not required for survival and does not control position-effect variegation (PEV).

Original languageEnglish (US)
Pages (from-to)317-322
Number of pages6
JournalGenetics
Volume179
Issue number1
DOIs
StatePublished - May 2008

All Science Journal Classification (ASJC) codes

  • Genetics

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