Functional cloning of genes involved in T-cell receptor-induced programmed cell death

Luciano D'Adamio, Emanuela Lacana', Pasquale Vito

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Programmed cell death (PCD) is a normal event under genetic control that regulates the life span of different cell types in multicellular organisms. Among other physiological processes, PCD plays a pivotal rob in the regulation of the immune system. Using a functional selection strategy we have isolated and characterized genes involved in T-cell receptor-induced apoptosis. One, ALG-2, is a Ca 2+ -binding protein, that participates in regulatory events that occur late in the apoptotic program where several death signals converge. Another, ALG-3, is a mouse homologue of the chromosome 1 familial Alzheimer's disease gene PS2. ALG-3 codes for a truncated PS2 polypeptide that antagonizes the apoptotic role of PS2. A PS2 mutation associated with Alzheimer's discase generates a molecule with enhanced apoptotic activity indicating that it might accelerate the process of neurodegeneration that occurs in this disease.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalSeminars in Immunology
Volume9
Issue number1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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T-Cell Antigen Receptor
Organism Cloning
Cell Death
Chymopapain
Physiological Phenomena
Chromosomes, Human, Pair 1
Genes
Immune System
Alzheimer Disease
Apoptosis
Peptides
Mutation
Ca-binding protein 2

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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Functional cloning of genes involved in T-cell receptor-induced programmed cell death. / D'Adamio, Luciano; Lacana', Emanuela; Vito, Pasquale.

In: Seminars in Immunology, Vol. 9, No. 1, 01.01.1997, p. 17-23.

Research output: Contribution to journalArticle

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