Functional heterogeneity in the bed nucleus of the stria terminalis

Nur Zeynep Gungor, Denis Paré

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Early work stressed the differing involvement of the central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) in the genesis of fear versus anxiety, respectively. In 2009, Walker, Miles, and Davis proposed a model of amygdala-BNST interactions to explain these functional differences. This model became extremely influential and now guides a new wave of studies on the role of BNST in humans. Here, we consider evidence for and against this model, in the process highlighting central principles of BNST organization. This analysis leads us to conclude that BNST’s influence is not limited to the generation of anxiety-like responses to diffuse threats, but that it also shapes the impact of discrete threatening stimuli. It is likely that BNST-CeA interactions are involved in modulating responses to such threats. In addition, whereas current views emphasize the contributions of the anterolateral BNST region in anxiety, accumulating data indicate that the anteromedial and anteroventral regions also play a critical role. The presence of multiple functional subregions within the small volume of BNST raises significant technical obstacles for functional imaging studies in humans.

Original languageEnglish (US)
Pages (from-to)8038-8049
Number of pages12
JournalJournal of Neuroscience
Volume36
Issue number31
DOIs
StatePublished - Aug 3 2016

Fingerprint

Septal Nuclei
Anxiety
Amygdala
Fear

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Amygdala
  • Anxiety
  • BNST
  • Fear

Cite this

@article{c5ea8e7fcd384ec19090fb33d0d7e963,
title = "Functional heterogeneity in the bed nucleus of the stria terminalis",
abstract = "Early work stressed the differing involvement of the central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) in the genesis of fear versus anxiety, respectively. In 2009, Walker, Miles, and Davis proposed a model of amygdala-BNST interactions to explain these functional differences. This model became extremely influential and now guides a new wave of studies on the role of BNST in humans. Here, we consider evidence for and against this model, in the process highlighting central principles of BNST organization. This analysis leads us to conclude that BNST’s influence is not limited to the generation of anxiety-like responses to diffuse threats, but that it also shapes the impact of discrete threatening stimuli. It is likely that BNST-CeA interactions are involved in modulating responses to such threats. In addition, whereas current views emphasize the contributions of the anterolateral BNST region in anxiety, accumulating data indicate that the anteromedial and anteroventral regions also play a critical role. The presence of multiple functional subregions within the small volume of BNST raises significant technical obstacles for functional imaging studies in humans.",
keywords = "Amygdala, Anxiety, BNST, Fear",
author = "Gungor, {Nur Zeynep} and Denis Par{\'e}",
year = "2016",
month = "8",
day = "3",
doi = "10.1523/JNEUROSCI.0856-16.2016",
language = "English (US)",
volume = "36",
pages = "8038--8049",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "31",

}

Functional heterogeneity in the bed nucleus of the stria terminalis. / Gungor, Nur Zeynep; Paré, Denis.

In: Journal of Neuroscience, Vol. 36, No. 31, 03.08.2016, p. 8038-8049.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Functional heterogeneity in the bed nucleus of the stria terminalis

AU - Gungor, Nur Zeynep

AU - Paré, Denis

PY - 2016/8/3

Y1 - 2016/8/3

N2 - Early work stressed the differing involvement of the central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) in the genesis of fear versus anxiety, respectively. In 2009, Walker, Miles, and Davis proposed a model of amygdala-BNST interactions to explain these functional differences. This model became extremely influential and now guides a new wave of studies on the role of BNST in humans. Here, we consider evidence for and against this model, in the process highlighting central principles of BNST organization. This analysis leads us to conclude that BNST’s influence is not limited to the generation of anxiety-like responses to diffuse threats, but that it also shapes the impact of discrete threatening stimuli. It is likely that BNST-CeA interactions are involved in modulating responses to such threats. In addition, whereas current views emphasize the contributions of the anterolateral BNST region in anxiety, accumulating data indicate that the anteromedial and anteroventral regions also play a critical role. The presence of multiple functional subregions within the small volume of BNST raises significant technical obstacles for functional imaging studies in humans.

AB - Early work stressed the differing involvement of the central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) in the genesis of fear versus anxiety, respectively. In 2009, Walker, Miles, and Davis proposed a model of amygdala-BNST interactions to explain these functional differences. This model became extremely influential and now guides a new wave of studies on the role of BNST in humans. Here, we consider evidence for and against this model, in the process highlighting central principles of BNST organization. This analysis leads us to conclude that BNST’s influence is not limited to the generation of anxiety-like responses to diffuse threats, but that it also shapes the impact of discrete threatening stimuli. It is likely that BNST-CeA interactions are involved in modulating responses to such threats. In addition, whereas current views emphasize the contributions of the anterolateral BNST region in anxiety, accumulating data indicate that the anteromedial and anteroventral regions also play a critical role. The presence of multiple functional subregions within the small volume of BNST raises significant technical obstacles for functional imaging studies in humans.

KW - Amygdala

KW - Anxiety

KW - BNST

KW - Fear

UR - http://www.scopus.com/inward/record.url?scp=84982958001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84982958001&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.0856-16.2016

DO - 10.1523/JNEUROSCI.0856-16.2016

M3 - Article

C2 - 27488624

AN - SCOPUS:84982958001

VL - 36

SP - 8038

EP - 8049

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 31

ER -