Functional heterogeneity of human rheumatoid synovial tissue macrophages

A. E. Koch, P. J. Polverini, S. J. Leibovich

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Neovascularization plays an important role in the formation of the rheumatoid (RA) synovial pannus. A subpopulation of RA macrophages (F3) (density 1.042-1.062 g/ml) has been shown to induce neovascularization in an in vivo rat corneal model of angiogenesis. We have found that conditioned medium from F3 macrophages induced significantly more endothelial migration (p<0.001) and mononuclear cell factor activity (p<0.001) than did conditioned medium from F2 macrophages (density 0.998-1.042 g/ml). Exposure of these macrophages to lipopolysaccharide did not increase production of these activities. RA synovial tissue macrophages appear to be (1) heterogeneous in their production, and (2) maximally activated for expression of these activities in vivo. F3 macrophages may be important in mediating both the fibroproliferative and destructive phases of RA.

Original languageEnglish (US)
Pages (from-to)1058-1063
Number of pages6
JournalJournal of Rheumatology
Issue number7
StatePublished - 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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