Fungal endophytes as efficient sources of plant-derived bioactive compounds and their prospective applications in natural product drug discovery: Insights, avenues, and challenges

Archana Singh, Dheeraj K. Singh, Ravindra N. Kharwar, James F. White, Surendra K. Gond

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Fungal endophytes are well-established sources of biologically active natural compounds with many producing pharmacologically valuable specific plant-derived products. This review details typical plant-derived medicinal compounds of several classes, including alkaloids, couma-rins, flavonoids, glycosides, lignans, phenylpropanoids, quinones, saponins, terpenoids, and xan-thones that are produced by endophytic fungi. This review covers the studies carried out since the first report of taxol biosynthesis by endophytic Taxomyces andreanae in 1993 up to mid-2020. The article also highlights the prospects of endophyte-dependent biosynthesis of such plant-derived pharmacologically active compounds and the bottlenecks in the commercialization of this novel approach in the area of drug discovery. After recent updates in the field of ‘omics’ and ‘one strain many compounds’ (OSMAC) approach, fungal endophytes have emerged as strong unconven-tional source of such prized products.

Original languageEnglish (US)
Article number197
Pages (from-to)1-42
Number of pages42
JournalMicroorganisms
Volume9
Issue number1
DOIs
StatePublished - Jan 2021

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Virology

Keywords

  • Bioactive
  • Drug discovery
  • Endophytic fungi
  • Host-derived
  • Medicinal plants
  • Natural products
  • Plant-derived
  • Secondary metabolites

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