G-protein-coupled receptors and melanoma

Hwa Jin Lee, Brian Wall, Suzie Chen

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

G-protein-coupled receptors (GPCR) are the largest family of receptors with over 500 members. Evaluation of GPCR gene expression in primary human tumors identified over-expression of GPCR in several tumor types. Analysis of cancer samples in different disease stages also suggests that some GPCR may be involved in early tumor progression and others may play a critical role in tumor invasion and metastasis. Currently, >50% of drug targets to various human diseases are based on GPCR. In this review, the relationships between several GPCR and melanoma development and/or progression will be discussed. Finally, the possibility of using one or more of these GPCR as therapeutic targets in melanoma will be summarized.

Original languageEnglish (US)
Pages (from-to)415-428
Number of pages14
JournalPigment Cell and Melanoma Research
Volume21
Issue number4
DOIs
StatePublished - Aug 1 2008

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Dermatology

Keywords

  • G-protein-coupled-receptors
  • Melanocytes
  • Melanoma
  • Oncogenes

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