Galactose biosensors using composite polymers to prevent interferences

Paul Manowitz, Paul W. Stoecker, Alexander M. Yacynych

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


A biosensor using a composite polymer to prevent interferences was used in a flow injection analysis system for the detection of galactose in human plasma. The biosensor consisted of galactose oxidase immobilized on a platinized carbon electrode that had been modified with a composite polymer. The composite polymer showed improved selectivity to hydrogen peroxide compared with either of its individual polymeric components, Nafion and a copolymer of diaminobenzene and resorcinol. The composite polymer minimized the effect of possible interference from urate, ascorbate, and acetaminophen. This analytical system has a minimum detection limit of 50 μM, linearity to 6 mM, a storage stability of greater than 30 days, and a high sample throughput (approx. 120 samples/h).

Original languageEnglish (US)
Pages (from-to)359-370
Number of pages12
JournalBiosensors and Bioelectronics
Issue number3-4
StatePublished - 1995

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


  • 1
  • 3-diaminobenzene
  • 3-phenylenediamine
  • Nafion
  • biosensor
  • composite polymer
  • electropolymerization
  • galactose
  • galactose oxidase
  • interferences


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