TY - JOUR
T1 - Galactose biosensors using composite polymers to prevent interferences
AU - Stoecker, Paul W.
AU - Yacynych, Alexander M.
AU - Manowitz, Paul
N1 - Funding Information:
The authors would like to acknowledge Dr Gad Avigad, Dr Stanley Stein, Dr Ronald Poretz, and Henry Lackland for their helpful suggestions. This work was supported by grants from the UNICO Foundation and the National Institute on Alcohol Abuse and Alcoholism Grant No. R01-AA07799.
PY - 1997
Y1 - 1997
N2 - The development of biosensor that could detect low concentrations of galactose in human plasma is described. The objective required the development of an improved polymer coating to eliminate the effects of interferences at low current ranges. The use of a composite polymer to improve the protection of electrodes from electroactive interferences such as ascorbate, urate, and acetominophen, is demonstrated. The composite polymer consist of a non-conducting polymer of diaminobenzene and resorcinol and an anionic polymer of Nafion. The inclusion of the composite polymers facilitated the development of a sensitive galactose biosensor. The biosensor have a linear range from 50 microM to 6.0 mM, and a storage stability of one month. The biosensors demonstrated excellent recovery of plasma galactose.
AB - The development of biosensor that could detect low concentrations of galactose in human plasma is described. The objective required the development of an improved polymer coating to eliminate the effects of interferences at low current ranges. The use of a composite polymer to improve the protection of electrodes from electroactive interferences such as ascorbate, urate, and acetominophen, is demonstrated. The composite polymer consist of a non-conducting polymer of diaminobenzene and resorcinol and an anionic polymer of Nafion. The inclusion of the composite polymers facilitated the development of a sensitive galactose biosensor. The biosensor have a linear range from 50 microM to 6.0 mM, and a storage stability of one month. The biosensors demonstrated excellent recovery of plasma galactose.
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M3 - Conference article
AN - SCOPUS:0030645246
SN - 0743-0515
VL - 76
SP - 509
EP - 510
JO - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
JF - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
T2 - Proceedings of the 1997 Spring ACS Meeting
Y2 - 13 April 1997 through 17 April 1997
ER -