Ganglion cell complex loss in patients with type 1 diabetes: A 36-month retrospective study

Loka Thangamathesvaran, Sumana S. Kommana, Kim Duong, Bernard Szirth, Albert S. Khouri

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: To analyze changes over a 3-year period in ganglion cell complex (GCC) thickness in individuals with type 1 diabetes mellitus (T1DM) using spectral-domain optical coherence tomography (Optovue, Fremont, CA, USA). Methods: Thirty-seven individuals from "Friends for Life Conference" with T1DM and a 3-year history of GCC thickness measurements were included in the study. Data analysis using SPSS 22 and Excel StatPlus was completed to note the subgroups that had a significant change. Results: Significant decreases were noted in the following subgroups with slope in parenthesis. 1. Overall: GCC superior thickness OD (-0.48) 2. Male: GCC thickness OD (-0.86), GCC superior thickness OD (-0.735) 3. Body mass index (BMI) 25.0-29.9: GCC thickness OD (-0.48), GCC superior thickness OS (-0.915), GCC inferior thickness OD (-0.43) 4. Ages 10-20 years: GCC superior thickness OD (-0.635) 5. Duration of diabetes 10-20 years: GCC thickness OD (-1.055), GCC superior thickness OD (-0.99). CONCLUSION: GCC loss was noted in individuals who were males, those with BMIs of 25.0-29.9, and those who had diabetes for 10-20 years. Ganglion cell loss was also noted before the presence of any diabetic retinopathy, suggesting onset of neuronal loss before any vasculature changes.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalOman Journal of Ophthalmology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2019

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Keywords

  • Diabetic retinopathy
  • ganglion cell complex
  • neuronal cell loss
  • optical coherence tomography

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