Gangliosides offer partial protection in experimental allergic neuritis

R. W. Ledeen, B. Oderfeld‐Nowak, C. F. Brosnan, A. Cervone

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The effect of gangliosides on the clinical course of experimental allergic neuritis was tested in Lewis rats sensitized with bovine intradural root myelin in complete Freund's adjuvant. A mixture of bovine brain gangliosides (GM1, GD1a, GD1b, GT1b) was injected intramuscularly at a daily dose of 20 mg per kilogram of body weight, beginning 6 days after inoculation. The results from seven different experiments show that in most cases, the administered gangliosides were partially protective. Particularly striking was the reduction in mortality rate to half or less of saline‐injected controls. Cumulative clinical index scores were also significantly lower with gangliosides treatment in five of the seven experiments. The cause of the wide variability is not known, but it was noted that better results were obtained when the animals were sensitized with freshly isolated myelin.

Original languageEnglish (US)
Pages (from-to)S69-S74
JournalAnnals of Neurology
Volume27
Issue number1 S
DOIs
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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