Garlic extract favorably modifies markers of endothelial function in obese patients –randomized double blind placebo-controlled nutritional intervention

Monika Szulińska, Matylda Kręgielska-Narożna, Joanna Świątek, Paulina Styś, Barbara Kuźnar-Kamińska, Hieronim Jakubowski, Jarosław Walkowiak, Paweł Bogdański

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Objective: Garlic exerts a range of effects relevant to human health. However, its influence on the endothelium in obese individuals remains unknown. We aimed to determine the effects of garlic extract (GE) on arterial stiffness and markers of endothelial function. Methods: Ninety-two subjects were enrolled in this study. The participants were randomly assigned to receive 400 mg of GE or placebo daily for 3 months. The arterial stiffness index (SI) and markers of endothelial function such as high-sensitivity C-reactive protein (hsCRP), cholesterol (total, LDL, HDL), triglycerides, and plasminogen activator inhibitor 1 (PAI-1), as well as total antioxidant status (TAS) were quantified at baseline and the end of study. Results: At the end of study SI (p = 0.01), hsCRP (p < 0.001, PAI-1 (p < 0.001), LDL cholesterol (p < 0.001), and TAS (p < 0.01) were reduced in the GE-supplemented group, but not in the placebo group. Conclusion: This randomized, double-blind, placebo-controlled trial demonstrates that supplementation with GE favorably modifies endothelial biomarkers associated with cardiovascular risk and suggests that GE can be used to suppress chronic inflammation in obese individuals.

Original languageEnglish (US)
Pages (from-to)792-797
Number of pages6
JournalBiomedicine and Pharmacotherapy
Volume102
DOIs
StatePublished - Jun 2018

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • Endothelium
  • Garlic
  • Inflammation
  • Obesity

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