TY - JOUR
T1 - Garlic extract favorably modifies markers of endothelial function in obese patients –randomized double blind placebo-controlled nutritional intervention
AU - Szulińska, Monika
AU - Kręgielska-Narożna, Matylda
AU - Świątek, Joanna
AU - Styś, Paulina
AU - Kuźnar-Kamińska, Barbara
AU - Jakubowski, Hieronim
AU - Walkowiak, Jarosław
AU - Bogdański, Paweł
N1 - Publisher Copyright:
© 2018 Elsevier Masson SAS
PY - 2018/6
Y1 - 2018/6
N2 - Objective: Garlic exerts a range of effects relevant to human health. However, its influence on the endothelium in obese individuals remains unknown. We aimed to determine the effects of garlic extract (GE) on arterial stiffness and markers of endothelial function. Methods: Ninety-two subjects were enrolled in this study. The participants were randomly assigned to receive 400 mg of GE or placebo daily for 3 months. The arterial stiffness index (SI) and markers of endothelial function such as high-sensitivity C-reactive protein (hsCRP), cholesterol (total, LDL, HDL), triglycerides, and plasminogen activator inhibitor 1 (PAI-1), as well as total antioxidant status (TAS) were quantified at baseline and the end of study. Results: At the end of study SI (p = 0.01), hsCRP (p < 0.001, PAI-1 (p < 0.001), LDL cholesterol (p < 0.001), and TAS (p < 0.01) were reduced in the GE-supplemented group, but not in the placebo group. Conclusion: This randomized, double-blind, placebo-controlled trial demonstrates that supplementation with GE favorably modifies endothelial biomarkers associated with cardiovascular risk and suggests that GE can be used to suppress chronic inflammation in obese individuals.
AB - Objective: Garlic exerts a range of effects relevant to human health. However, its influence on the endothelium in obese individuals remains unknown. We aimed to determine the effects of garlic extract (GE) on arterial stiffness and markers of endothelial function. Methods: Ninety-two subjects were enrolled in this study. The participants were randomly assigned to receive 400 mg of GE or placebo daily for 3 months. The arterial stiffness index (SI) and markers of endothelial function such as high-sensitivity C-reactive protein (hsCRP), cholesterol (total, LDL, HDL), triglycerides, and plasminogen activator inhibitor 1 (PAI-1), as well as total antioxidant status (TAS) were quantified at baseline and the end of study. Results: At the end of study SI (p = 0.01), hsCRP (p < 0.001, PAI-1 (p < 0.001), LDL cholesterol (p < 0.001), and TAS (p < 0.01) were reduced in the GE-supplemented group, but not in the placebo group. Conclusion: This randomized, double-blind, placebo-controlled trial demonstrates that supplementation with GE favorably modifies endothelial biomarkers associated with cardiovascular risk and suggests that GE can be used to suppress chronic inflammation in obese individuals.
KW - Endothelium
KW - Garlic
KW - Inflammation
KW - Obesity
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U2 - 10.1016/j.biopha.2018.03.131
DO - 10.1016/j.biopha.2018.03.131
M3 - Article
C2 - 29604599
AN - SCOPUS:85054364461
SN - 0753-3322
VL - 102
SP - 792
EP - 797
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
ER -