TY - JOUR
T1 - Gas Phase Experimental and Computational Studies of AlkB Substrates
T2 - Intrinsic Properties and Biological Implications
AU - Zhang, Lanxin
AU - Ding, Xiao
AU - Kratka, Catherine R.
AU - Levine, Alec
AU - Lee, Jeehiun K.
N1 - Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/9/15
Y1 - 2023/9/15
N2 - The gas phase acidity and proton affinity of nucleobases that are substrates for the DNA repair enzyme AlkB have been examined using both computational and experimental methods. These thermochemical values have not heretofore been measured and provide experimental data that help benchmark the theoretical results. We also use our gas phase results to lend insight into the AlkB mechanism, particularly in terms of the role AlkB plays in DNA repair, versus its complementary enzyme AlkA.
AB - The gas phase acidity and proton affinity of nucleobases that are substrates for the DNA repair enzyme AlkB have been examined using both computational and experimental methods. These thermochemical values have not heretofore been measured and provide experimental data that help benchmark the theoretical results. We also use our gas phase results to lend insight into the AlkB mechanism, particularly in terms of the role AlkB plays in DNA repair, versus its complementary enzyme AlkA.
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U2 - 10.1021/acs.joc.3c01335
DO - 10.1021/acs.joc.3c01335
M3 - Article
AN - SCOPUS:85171536747
SN - 0022-3263
VL - 88
SP - 13115
EP - 13124
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 18
ER -