Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses

Sabine Kienesberger; Laura M. Cox; Alexandra Livanos; Xue Song Zhang; Jennifer Chung; Guillermo I. Perez-Perez; Gregor Gorkiewicz; Ellen L. Zechner; Martin J. Blaser

doi:10.1016/j.celrep.2016.01.017

Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses

Sabine Kienesberger, Laura M. Cox, Alexandra Livanos, Xue Song Zhang, Jennifer Chung, Guillermo I. Perez-Perez, Gregor Gorkiewicz, Ellen L. Zechner, Martin J. Blaser

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host's microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response genes, conserved across mice and over time in the stomach and more transiently in the lungs. Moreover, H. pylori infection led to significantly different population structures in both the gastric and intestinal microbiota. These studies indicate that H. pylori influences the microbiota and host immune responses not only locally in the stomach, but distantly as well, affecting important target organs.

Original language	English (US)
Pages (from-to)	1395-1407
Number of pages	13
Journal	Cell Reports
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2016.01.017
State	Published - Feb 16 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.celrep.2016.01.017

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title = "Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses",

abstract = "Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host's microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response genes, conserved across mice and over time in the stomach and more transiently in the lungs. Moreover, H. pylori infection led to significantly different population structures in both the gastric and intestinal microbiota. These studies indicate that H. pylori influences the microbiota and host immune responses not only locally in the stomach, but distantly as well, affecting important target organs.",

author = "Sabine Kienesberger and Cox, {Laura M.} and Alexandra Livanos and Zhang, {Xue Song} and Jennifer Chung and Perez-Perez, {Guillermo I.} and Gregor Gorkiewicz and Zechner, {Ellen L.} and Blaser, {Martin J.}",

note = "Funding Information: This study was supported by RO1 GM63270 from the NIH , the Bill and Melinda Gates Foundation , the Diane Belfer Program in Human Ecology (to. M.J.B.), the Michael Saperstein Medical Scholars Program (to S.K.), and the BioTechMed Graz Program (to E.L.Z.). We thank Isabel Teitler for her contributions to this work and Hao Chen for help with data deposition. This work has utilized computing resources at the High Performance Computing Facility of the Center for Health Informatics and Bioinformatics (CHIBI) at the NYU Langone Medical Center. Publisher Copyright: {\textcopyright} 2016 The Authors.",

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AU - Kienesberger, Sabine

AU - Cox, Laura M.

AU - Livanos, Alexandra

AU - Zhang, Xue Song

AU - Chung, Jennifer

AU - Perez-Perez, Guillermo I.

AU - Gorkiewicz, Gregor

AU - Zechner, Ellen L.

AU - Blaser, Martin J.

N1 - Funding Information: This study was supported by RO1 GM63270 from the NIH , the Bill and Melinda Gates Foundation , the Diane Belfer Program in Human Ecology (to. M.J.B.), the Michael Saperstein Medical Scholars Program (to S.K.), and the BioTechMed Graz Program (to E.L.Z.). We thank Isabel Teitler for her contributions to this work and Hao Chen for help with data deposition. This work has utilized computing resources at the High Performance Computing Facility of the Center for Health Informatics and Bioinformatics (CHIBI) at the NYU Langone Medical Center. Publisher Copyright: © 2016 The Authors.

PY - 2016/2/16

Y1 - 2016/2/16

N2 - Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host's microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response genes, conserved across mice and over time in the stomach and more transiently in the lungs. Moreover, H. pylori infection led to significantly different population structures in both the gastric and intestinal microbiota. These studies indicate that H. pylori influences the microbiota and host immune responses not only locally in the stomach, but distantly as well, affecting important target organs.

AB - Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host's microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response genes, conserved across mice and over time in the stomach and more transiently in the lungs. Moreover, H. pylori infection led to significantly different population structures in both the gastric and intestinal microbiota. These studies indicate that H. pylori influences the microbiota and host immune responses not only locally in the stomach, but distantly as well, affecting important target organs.

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Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses

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