Gastrin-releasing peptide in hypoplastic lungs

Joan Durbin, Patricia Thomas, Claire Langston, Sunanda Goswami, M. Alba Greco

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The relative abundance of pulmonary neuroendocrine cells synthesizing gastrin-releasing peptide (GRP) was estimated for normal fetal lungs and hypoplastic lungs. Percentage of bronchiolar epithelial area staining positively with anti-GRP antiserum was computed for each case using a SAMBA 4000 image analyzer. The majority of hypoplastic lungs (10 of 12 cases) showed markedly diminished GRP immunoreactivity, which appeared to vary with etiology. Six cases of pulmonary hypoplasia associated with renal anomalies, three cases associated with hydrops and one case of diaphragmatic hernia showed an average fivefold reduction in percentage of GRP immunostaining. A case of hypoplasia associated with Werdnig-Hoffmann disease had GRP immunoreactivity similar to that of controls, and GRP expression was markedly elevated (fivefold) in a case of hypoplasia with omphalocele.

Original languageEnglish (US)
Pages (from-to)927-934
Number of pages8
JournalPediatric Pathology and Laboratory Medicine
Volume16
Issue number6
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Keywords

  • fetal lung
  • gastrin-releasing peptide
  • image analysis
  • immunohistochemistry
  • neuroendocrine cells
  • pulmonary hypoplasia

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