Gene transcription in trypanosomes

Jennifer B. Palenchar; Vivian Bellofatto

doi:10.1016/j.molbiopara.2005.12.008

Gene transcription in trypanosomes

Jennifer B. Palenchar, Vivian Bellofatto

New Jersey Medical School (NJMS), Microbiology

Research output: Contribution to journal › Review article › peer-review

105 Scopus citations

Abstract

Trypanosoma brucei and the other members of the trypanosomatid family of parasitic protozoa, contain an unusual RNA polymerase II enzyme, uncoordinated mRNA 5′ capping and transcription initiation events, and most likely contain an abridged set of transcription factors. Pre-mRNA start sites remain elusive. In addition, two important life cycle stage-specific mRNAs are transcribed by RNA polymerase I. This review interprets these unusual transcription traits in the context of parasite biology.

Original language	English (US)
Pages (from-to)	135-141
Number of pages	7
Journal	Molecular and Biochemical Parasitology
Volume	146
Issue number	2
DOIs	https://doi.org/10.1016/j.molbiopara.2005.12.008
State	Published - Apr 2006

All Science Journal Classification (ASJC) codes

Parasitology
Molecular Biology

Keywords

Basal transcription factors
RNA polymerases
Trypanosomes

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10.1016/j.molbiopara.2005.12.008

Cite this

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abstract = "Trypanosoma brucei and the other members of the trypanosomatid family of parasitic protozoa, contain an unusual RNA polymerase II enzyme, uncoordinated mRNA 5′ capping and transcription initiation events, and most likely contain an abridged set of transcription factors. Pre-mRNA start sites remain elusive. In addition, two important life cycle stage-specific mRNAs are transcribed by RNA polymerase I. This review interprets these unusual transcription traits in the context of parasite biology.",

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AB - Trypanosoma brucei and the other members of the trypanosomatid family of parasitic protozoa, contain an unusual RNA polymerase II enzyme, uncoordinated mRNA 5′ capping and transcription initiation events, and most likely contain an abridged set of transcription factors. Pre-mRNA start sites remain elusive. In addition, two important life cycle stage-specific mRNAs are transcribed by RNA polymerase I. This review interprets these unusual transcription traits in the context of parasite biology.

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KW - RNA polymerases

KW - Trypanosomes

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Gene transcription in trypanosomes

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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