Gene transcription in trypanosomes

Jennifer B. Palenchar, Vivian Bellofatto

Research output: Contribution to journalReview articlepeer-review

103 Scopus citations

Abstract

Trypanosoma brucei and the other members of the trypanosomatid family of parasitic protozoa, contain an unusual RNA polymerase II enzyme, uncoordinated mRNA 5′ capping and transcription initiation events, and most likely contain an abridged set of transcription factors. Pre-mRNA start sites remain elusive. In addition, two important life cycle stage-specific mRNAs are transcribed by RNA polymerase I. This review interprets these unusual transcription traits in the context of parasite biology.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalMolecular and Biochemical Parasitology
Volume146
Issue number2
DOIs
StatePublished - Apr 2006

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Molecular Biology

Keywords

  • Basal transcription factors
  • RNA polymerases
  • Trypanosomes

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