Genetic analysis of host resistance to intracellular pathogens: lessons from studies of Toxoplasma gondii infection

George S. Yap, Michael H. Shaw, Yun Ling, Alan Sher

Research output: Contribution to journalShort surveypeer-review

32 Scopus citations

Abstract

Cell-mediated immunity to Toxoplasma gondii establishes and maintains a balanced host-pathogen relationship. Recent analyses using spontaneous and genetically engineered mouse mutants have yielded a clearer picture of factors positively and negatively regulating the host immune response and a better understanding of cytokine-inducible intracytoplasmic mechanisms that lead to intracellular pathogen suppression and demise.

Original languageEnglish (US)
Pages (from-to)1174-1178
Number of pages5
JournalMicrobes and Infection
Volume8
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Infectious Diseases

Keywords

  • Cytokine
  • Innate immunity
  • Toxoplasma gondii

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