Genetic association of GABA-A receptor alpha-2 and Mu opioid receptor with cocaine Cue-reactivity: Evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence

David Smelson, Lei Yu, Steven Buyske, Gerardo Gonzalez, Jay Tischfield, Curtis K. Deutsch, Douglas Ziedonis

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: This pilot feasibility study examined the role of genetics in laboratory-induced cocaine craving. Methods: Thirty-four African American, cocaine-dependent male subjects underwent a baseline assessment, cue-exposure session, and genetic analysis. Subjects were classified as either cue-reactive or nonreactive. Results: Among single nucleotide polymorphism markers in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p=.001) and OPRM1 (coding for mu opioid receptor; rs2236256, nominal p=.03). Conclusions: These pilot results suggest that cocaine craving shows variability among cocaine-dependent subjects, and that GABRA2 and OPRM1 polymorphisms have differential influences on cocaine cue-reactivity, warranting studies in future research.

Original languageEnglish (US)
Pages (from-to)411-415
Number of pages5
JournalAmerican Journal on Addictions
Volume21
Issue number5
DOIs
StatePublished - Sep 1 2012

Fingerprint

Cocaine-Related Disorders
mu Opioid Receptor
GABA-A Receptors
Cocaine
Synaptic Transmission
Cues
Feasibility Studies
African Americans
Single Nucleotide Polymorphism
Genes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

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Genetic association of GABA-A receptor alpha-2 and Mu opioid receptor with cocaine Cue-reactivity : Evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. / Smelson, David; Yu, Lei; Buyske, Steven; Gonzalez, Gerardo; Tischfield, Jay; Deutsch, Curtis K.; Ziedonis, Douglas.

In: American Journal on Addictions, Vol. 21, No. 5, 01.09.2012, p. 411-415.

Research output: Contribution to journalArticle

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AU - Ziedonis, Douglas

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