Genetic homology between man and the chimpanzee: Syntenic relationships of genes for galactokinase and thymidine kinase and adenovirus-12-induced gaps using chimpanzee-mouse somatic cell hybrids

Suzie Chen, James K. McDougall, Richard P. Creagan, Valerie Lewis, Frank H. Ruddle

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The induction by adenovirus-12 of a site-specific gap and assignment of the chimpanzee genes for thymidine kinase and galactokinase were studied by utilizing chimpanzee-mouse hybrid cells. It has been shown that adenovirus-12 induces a specific gap in the long arm of human chromosome 17 (HS 17); with chimpanzee-mouse hybrid cells the specific gap appears on the short arm of the chimpanzee homolog [PTR 19 (HS 17)] of HS 17. This result supports the proposed relationship of HS 17 to PTR 19 (HS 17) by means of a pericentric inversion. The chimpanzee thymidine kinase and galactokinase genes were assigned to PTR 19 (HS 17), further confirming the homology to HS 17. Other syntenic relationships and gene assignments were consistent with proposed homologies between chimpanzee and human chromosomes.

Original languageEnglish (US)
Pages (from-to)205-213
Number of pages9
JournalSomatic Cell Genetics
Volume2
Issue number3
DOIs
StatePublished - May 1 1976
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

Fingerprint Dive into the research topics of 'Genetic homology between man and the chimpanzee: Syntenic relationships of genes for galactokinase and thymidine kinase and adenovirus-12-induced gaps using chimpanzee-mouse somatic cell hybrids'. Together they form a unique fingerprint.

Cite this