Genetic mapping by single sperm typing

N. ARNHEIM, H. LI, X. CUI

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Summary. The polymerase chain reaction makes it possible to analyse DNA sequences in a single cell and has led to a new approach for constructing genetic maps. We describe a procedure called ‘sperm typing’ which can accurately classify individual meiotic products as recombinant or non‐recombinant. This permits the linkage relationships among DNA polymorphisms to be determined without pedigree analysis.

Original languageEnglish (US)
Pages (from-to)105-115
Number of pages11
JournalAnimal Genetics
Volume22
Issue number2
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Genetics

Keywords

  • PCR
  • genetic mapping
  • recombination
  • sperm typing

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