Genetics of the febrile seizure susceptibility trait

Steven L. Kugler, William G. Johnson

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Febrile seizures are the commonest form of convulsion, occurring in 2-5% of infants in Europe and North America and 6-9% of infants in Japan. In large families, the febrile seizure susceptibility trait is inherited by the autosomal dominant pattern with reduced penetrance. In the other families, inheritance appears to be multifactorial. Recent linkage studies provide evidence that regions of chromosomes 8 and 19 contain febrile convulsions (FC) susceptibility genes. This opens up the way to cloning a febrile seizure gene and determining the contributions of these gene loci to febrile seizures in the sporadic cases and the small families. Cloning a febrile seizure gene will make possible new approaches to prevention and therapy. It will also be possible to determine whether a febrile seizure gene contributes to other types of seizures.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalBrain and Development
Issue number5
StatePublished - Aug 1998

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology


  • Febrile seizures
  • Genetics
  • Human chromosome 19
  • Human chromosome 8
  • Linkage analysis


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