Genome scanning for complex disease genes using the transmission/disequilibrium test and haplotype‐based haplotype relative risk

Two tests for allelic association were applied to a simulated complex disease for the Genetic Analysis Workshop 9. The transmission/disequilibrium test [Spielman et al., 1993] and the haplotype‐based haplotype relative risk approach [Terwilliger and Ott, 1992] were used to detect disease‐associated alleles in a set of 360 computer‐simulated markers located on six chromosomes and genotyped in 200 nuclear families. This analysis emulates a genome‐based search for linked markers. Computer simulations were also performed to clarify statistical properties of the TDT. ©1995 Wiley‐Liss, Inc.