Genome-wide association study of esophageal squamous cell carcinoma in chinese subjects identifies a susceptibility locus at PLCE1

Li Dong Wang, Fu You Zhou, Xue Min Li, Liang Dan Sun, Xin Song, Yan Jin, Jiang Man Li, Guo Qiang Kong, Hong Qi, Juan Cui, Lian Qun Zhang, Jie Zhi Yang, Ji Lin Li, Xing Chuan Li, Jing Li Ren, Zhi Cai Liu, Wen Jun Gao, Ling Yuan, Wu Wei, Yan Rui ZhangWei Peng Wang, Ilyar Sheyhidin, Feng Li, Bao Ping Chen, Shu Wei Ren, Bin Liu, Dan Li, Jian Wei Ku, Zong Min Fan, Sheng Li Zhou, Zhi Gang Guo, Xue Ke Zhao, Na Liu, Yong Hong Ai, Fang Fang Shen, Wen Yan Cui, Shuang Song, Tao Guo, Jing Huang, Chao Yuan, Jia Huang, Yue Wu, Wen Bin Yue, Chang Wei Feng, Hong Lei Li, Yan Wang, Jin Ya Tian, Yue Lu, Yi Yuan, Wen Liang Zhu, Min Liu, Wen Jing Fu, Xia Yang, Han Jing Wang, Suo Li Han, Jie Chen, Min Han, Hai Yan Wang, Peng Zhang, Xiu Min Li, Jin Cheng Dong, Guo Lan Xing, Ran Wang, Ming Guo, Zhi Wei Chang, Hai Lin Liu, Li Guo, Zhi Qing Yuan, Hai Liu, Qin Lu, Liu Qin Yang, Fu Guo Zhu, Xiu Feng Yang, Xiao Shan Feng, Zhou Wang, Yin Li, She Gan Gao, Qirenwang Qige, Long Tang Bai, Wen Jun Yang, Guang Yan Lei, Zhong Ying Shen, Long Qi Chen, En Min Li, Li Yan Xu, Zhi Yong Wu, Wei Ke Cao, Jian Po Wang, Zhi Qin Bao, Ji Li Chen, Guang Cheng Ding, Xiang Zhuang, Ying Fa Zhou, Hou Feng Zheng, Zheng Zhang, Xian Bo Zuo, Zi Ming Dong, Dong Mei Fan, Xin He, Jin Wang, Qi Zhou, Qin Xian Zhang, Xin Ying Jiao, Shi Yong Lian, Ai Fang Ji, Xiao Mei Lu, Jin Sheng Wang, Fu Bao Chang, Chang Dong Lu, Zhi Guo Chen, Jian Jun Miao, Zeng Lin Fan, Ruo Bai Lin, Tai Jiang Liu, Jin Chang Wei, Qing Peng Kong, Yu Lan, Yu Jing Fan, Fu Sheng Gao, Tian Yun Wang, Dong Xie, Shu Qing Chen, Wan Cai Yang, Jun Yan Hong, Liang Wang, Song Liang Qiu, Zhi Ming Cai, Xue Jun Zhang

Research output: Contribution to journalLetter

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Abstract

We performed a genome-wide association study of esophageal squamous cell carcinoma (ESCC) by genotyping I, 077 individuals with ESCC and 1, 733 control subjects of Chinese Han descent. We selected 18 promising SNPs for replication in an additional 7, 673 cases of ESCC and 11, 013 control subjects of Chinese Han descent and 303 cases of ESCC and 537 control subjects of Chinese Uygur-Kazakh descent. We identified a previously unknown susceptibility locus for ESCC: PLCE1 at 1 0q23 (pHan combined for ESCC = 7.46 X 10-56, odds ratio (OR) = 1.43; Puygur-Kazakh for ESCC = 5.70 X 10-4, OR = 1.53). We also confirmed association in 2, 766 cases of gastric cardia adenocarcinoma and the same II, 013 control subjects (PLCE1, PHan for GCA = 1.74 X 10-39, OR = 1.55). PLCE1 has important biological implications for both ESCC and GCA. PLCE1 might regulate cell growth, differentiation, apoptosis and angiogenesis.

Original languageEnglish (US)
Pages (from-to)759-765
Number of pages7
JournalNature genetics
Volume42
Issue number9
DOIs
StatePublished - Sep 2010

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All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Wang, L. D., Zhou, F. Y., Li, X. M., Sun, L. D., Song, X., Jin, Y., Li, J. M., Kong, G. Q., Qi, H., Cui, J., Zhang, L. Q., Yang, J. Z., Li, J. L., Li, X. C., Ren, J. L., Liu, Z. C., Gao, W. J., Yuan, L., Wei, W., ... Zhang, X. J. (2010). Genome-wide association study of esophageal squamous cell carcinoma in chinese subjects identifies a susceptibility locus at PLCE1. Nature genetics, 42(9), 759-765. https://doi.org/10.1038/ng.648