Genus-specific substitution rate variability among picornaviruses

Allison L. Hicks, Siobain Duffy

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Picornaviruses have some of the highest nucleotide substitution rates among viruses, but there have been no comparisons of evolutionary rates within this broad family. We combined our own Bayesian coalescent analyses of VP1 regions from four picornaviruses with 22 published VP1 rates to produce the first within-family meta-analysis of viral evolutionary rates. Similarly, we compared our rate estimates for the RNA polymerase 3D pol gene from five viruses to four published 3D pol rates. Both a structural and a nonstructural gene show that enteroviruses are evolving, on average, a half order of magnitude faster than members of other genera within the Picornaviridae family.

Original languageEnglish (US)
Pages (from-to)7942-7947
Number of pages6
JournalJournal of virology
Issue number15
StatePublished - Aug 2011

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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