Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics

Dacheng Peng, Huashan Wang, Chenling Qu, Laihua Xie, Sheila M. Wicks, Jingtian Xie

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Ginsenosides, the bioactive components of ginseng, can be divided into two major groups, namely 20(S)-protopanaxatriol (e.g. Re, Rg 1, Rg 2, and Rb 3) and 20(S)-protopanaxadiol (e.g. Rb 1, Rb 2, Rc, and Rd). Biological and environmental factors may affect the content of ginsenosides in different parts of ginseng plant. Evidence from pharmacokinetic and metabolic studies of Re demonstrated that (1) the absorption of Re is fast in gastrointestinal tract; (2) Re may be metabolized mainly to Rh 1 and F 1 by intestinal microflora before absorption into blood; and (3) Re is quickly cleared from the body.

Original languageEnglish (US)
Article number2
JournalChinese Medicine
Volume7
DOIs
StatePublished - Feb 7 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Complementary and alternative medicine

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