Glucagon-like peptide-1 drives energy metabolism on the synaptic highway

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Glucagon-like peptide-1 (GLP-1), a gut–brain hormone, coordinates energy balance in both peripheral organs and the central nervous system (CNS). In the pancreas, GLP-1 facilitates insulin exocytosis or suppresses glucagon exocytosis via multiple pathways such as regulating KATP/Kv channels, N-type Ca2+ channels, and the readily releasable pool. In the CNS, GLP-1 signaling regulates neuronal excitability in various brain regions, including neurons in the hippocampus, hypothalamus, and mesolimbic systems. GLP-1 modulation on synaptic transmission includes both pre- and postsynaptic pathways that are either excitatory or inhibitory. Synaptic transmission conveys information flow in the brain and governs brain-mediated behaviors. The study of GLP-1 control of energy metabolism at a synaptic level may shed light on the role of GLP-1 function in the brain. Various challenges remain including defining the mechanism of GLP-1 release in the brain.

Original languageEnglish (US)
Pages (from-to)4413-4423
Number of pages11
JournalFEBS Journal
Issue number24
StatePublished - Dec 1 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


  • GPCR
  • diabetes
  • energy metabolism
  • glucagon-like peptide-1
  • synaptic transmission


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