Glutamatergic signaling by midbrain dopaminergic neurons: Recent insights from optogenetic, molecular and behavioral studies

Tibor Koos, Fatuel Tecuapetla, James Tepper

Research output: Contribution to journalReview article

18 Scopus citations


Although the notion that dopaminergic neurons utilize glutamate as a co-transmitter has long been supported by tantalizing molecular, immunocytochemical and electrophysiological evidence it has only been with the recent addition of optogenetic and other approaches that the existence and functional relevance of this mechanism could be unambiguously demonstrated. Here we discuss the possible mechanisms of action of glutamate released from mesoaccumbens dopaminergic neurons based on recently accumulated evidence. Surprisingly, rather then to confirm a role in conventional fast excitatory transmission, the latest evidence suggests that glutamate released from dopaminergic neurons may primarily act through different unconventional presynaptic and postsynaptic mechanisms.

Original languageEnglish (US)
Pages (from-to)393-401
Number of pages9
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 1 2011


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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