Glutamine and glutamate metabolism across the liver sinusoid

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Abstract

The liver shows net glutamine uptake after a protein-containing meal, during uncontrolled diabetes, sepsis and short-term starvation, but changes to net release during long-term starvation and metabolic acidosis. Some studies report a small net release of glutamate by the liver. The differential expression of glutamine synthetase (perivenous) and glutaminase (periportal) within the liver indicates that glutamine is used for urea synthesis in periportal cells, whereas glutamine synthesis serves to detoxify any residual ammonia in perivenous cells. Experiments in vivo suggest that changes in net hepatic glutamine balance are due predominantly to regulation of glutaminase activity, with the flux through glutamine synthetase being relatively constant.

Original languageEnglish (US)
Pages (from-to)983S-987S
JournalJournal of Nutrition
Volume130
Issue number4 SUPPL.
DOIs
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Keywords

  • Ammonia
  • Glutamate
  • Glutaminase
  • Glutamine
  • Glutamine synthetase
  • Liver
  • Urea cycle

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