Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis

Vishwanath Venketaraman, Yaswant K. Dayaram, Meliza T. Talaue, Nancy D. Connell

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)1886-1889
Number of pages4
JournalInfection and immunity
Volume73
Issue number3
DOIs
StatePublished - Mar 2005

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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