Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis

Vishwanath Venketaraman; Yaswant K. Dayaram; Meliza T. Talaue; Nancy D. Connell

doi:10.1128/IAI.73.3.1886-1889.2005

Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis

Vishwanath Venketaraman
, Yaswant K. Dayaram
, Meliza T. Talaue
, Nancy D. Connell

New Jersey Medical School (NJMS), Medicine, Division of Infectious Disease

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.

Original language	English (US)
Pages (from-to)	1886-1889
Number of pages	4
Journal	Infection and immunity
Volume	73
Issue number	3
DOIs	https://doi.org/10.1128/IAI.73.3.1886-1889.2005
State	Published - Mar 2005

All Science Journal Classification (ASJC) codes

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.73.3.1886-1889.2005

Cite this

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title = "Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis",

abstract = "We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.",

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N2 - We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.

AB - We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.

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SN - 0019-9567

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Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis

Abstract

All Science Journal Classification (ASJC) codes

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