Glycogen synthase kinase-3β a novel regulator of cardiac hypertrophy and development

Stefan E. Hardt, Junichi Sadoshima

Research output: Contribution to journalReview articlepeer-review

325 Scopus citations

Abstract

Glycogen synthase kinase-3β (GSK-3β) is a ubiquitously expressed constitutively active serine/threonine kinase that phosphorylates cellular substrates and thereby regulates a wide variety of cellular functions, including development, metabolism, gene transcription, protein translation, cytoskeletal organization, cell cycle regulation, and apoptosis. The activity of GSK-3β is negatively regulated by protein kinase B/Akt and by the Wnt signaling pathway, Increasing lines of evidence show that GSK-3β is an essential negative regulator of cardiac hypertrophy and that the inhibition of GSK-3β by hypertrophic stimuli is an important mechanism contributing to the development of cardiac hypertrophy. GSK-3β also plays an important role in regulating cardiac development, In this review, the role of GSK-3β in cardiac hypertrophy and development and the potential underlying mechanisms are discussed.

Original languageEnglish (US)
Pages (from-to)1055-1063
Number of pages9
JournalCirculation research
Volume90
Issue number10
DOIs
StatePublished - May 31 2002

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Keywords

  • Akt
  • Development
  • Glycogen synthase kinase-3β
  • Hypertrophy
  • Wnt pathway

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