Glycomimetic cyclic peptides stimulate neurite outgrowth

Dirk Bächle, Gabriele Loers, Eckhart W. Guthöhrlein, Melitta Schachner, Norbert Sewald

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

(Figure Presented) Alternative mimetics: Short cyclic hexapeptides (see picture; blue N, red O, white H, gray C) can be effective for oligosaccharide mimicry. The individual contributions of cyclization, amino acid stereo-chemistry, turn position, and side-chain functionality to the glycomimetic properties of the peptides were identified. Two peptides proved to be high-affinity ligands for the 412 antibody and also showed enhanced functional activity as HNK-1 mimetics.

Original languageEnglish (US)
Pages (from-to)6582-6585
Number of pages4
JournalAngewandte Chemie - International Edition
Volume45
Issue number39
DOIs
StatePublished - Oct 6 2006

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • Bioorganic chemistry
  • Glycomimetics
  • Neuroactive substances
  • Neurochemistry
  • Peptides

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