(Figure Presented) Alternative mimetics: Short cyclic hexapeptides (see picture; blue N, red O, white H, gray C) can be effective for oligosaccharide mimicry. The individual contributions of cyclization, amino acid stereo-chemistry, turn position, and side-chain functionality to the glycomimetic properties of the peptides were identified. Two peptides proved to be high-affinity ligands for the 412 antibody and also showed enhanced functional activity as HNK-1 mimetics.
All Science Journal Classification (ASJC) codes
- Bioorganic chemistry
- Neuroactive substances